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Alzheimer's Disease and beta-amyloid (Abeta)

Compiled and edited by: Joe Hing kwok Chu

 

Inhaled anesthesia can enhance Abeta - oligomerization and cytotoxicity [1]

Light to moderate alcohol consumption is associated with S100beta  and amyloid beta level in healthy older adults. [2]

Elevated S100beta levels may indicate the presence of radiologically detectable blood brain barrier leakage.[4]

Using benzodiazepine drug may increase the chance of getting Alzheimer's disease. [5]

Using a steroid type of chemical to activates pregnane X receptor (PXR), the amount of beta-amyloid protein in the brain is reduced in the genetically modified mice expressing with human abeta. The activation of the PXR was found to increase the expression of a blood-brain barrier protein known as P-glycoprotein. This protein transports beta-amyloid out of the brain. [3]

The controlled lowering of systemic copper may achieve anti-amyloid effects if initiated early in the disease process. [6]

Back to Alzheimer's D page.

See: beng da wan (Centella Asiatica)

 

 

[1]http://journals.lww.com/anesthesiology/Fulltext/2004/09000/Inhaled_Anesthetic_Enhancement_of_Amyloid__beta_.19.aspx

[2] http://www.ncbi.nlm.nih.gov/pubmed/18351497
[3]
http://www.nih.gov/news/health/apr2010/niehs-12.htm

[4] http://www.ncbi.nlm.nih.gov/pubmed/12767094

[5] BMJ. 2014; 349: g5205.

[6] J Alzheimers Dis. 2010 Jan 1; 21(3): 903914.; doi: 10.3233/JAD-2010-100408

 

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