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Alzheimer's Disease and beta-amyloid (Abeta)
Edited by: Joe Hing kwok Chu
Light to moderate alcohol consumption is associated with and amyloid beta level in healthy older adults. 
Using a steroid type of chemical to activates pregnane X receptor (PXR), the amount of beta-amyloid protein in the brain is reduced in the genetically modified mice expressing with human abeta. The activation of the PXR was found to increase the expression of a blood-brain barrier protein known as P-glycoprotein. This protein transports beta-amyloid out of the brain. 
Elevated S100beta levels may indicate the presence of radiologically detectable blood brain barrier leakage.
Using benzodiazepine drug may increase the chance of getting Alzheimer's disease. 
 BMJ. 2014; 349: g5205.
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