Alzheimer's Disease and beta-amyloid (Abeta)
Edited by: Joe Hing kwok Chu
Light to moderate alcohol consumption is associated with and amyloid beta level in healthy older adults. 
Using a steroid type of chemical to activates pregnane X receptor (PXR), the amount of beta-amyloid protein in the brain is reduced in the genetically modified mice expressing with human abeta. The activation of the PXR was found to increase the expression of a blood-brain barrier protein known as P-glycoprotein. This protein transports beta-amyloid out of the brain. 
Elevated S100beta levels may indicate the presence of radiologically detectable blood brain barrier leakage.
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