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chuan xin lian ¬ï ¤ß ½¬

by: Joe Hing Kwok Chu

¬ï ¤ß ½¬ ¡@
Pharmaceutical name: Herb andrographitis paniculatae
Biological name: Andrographis paniculata (Burm. F.) Nees
Pron. in Japanese: senhinren
Pron. in Korean: chonsimyon
Pron. in Cantonese: chun sam lian
Common Name: green chiretta
Distribution: Guangdong, Guangxi, Fujian, Yunnan, Sichuan, Jiangsu, Jiangxi provinces
Properties (characteristics) bitter, cold
Channels (meridians) entered: lungs, large intestine, bladder
Actions & Indications: clear heat and toxins, cool blood, reduce swelling, for fever in influenza, swelling and pain in throat, boils in mouth and tongue, chronic cough, diarrhea, painful urination, snake bites

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Medical Function:
  1. The whole herb possess antibiotic, antiviral, antipyretic and ridding of parasite effect
  2. 5 to 40% of decoction, to different degrees, inhibits Staphylococcus aureaus, Pseudomonas aeruginosa, Shigella dysenteriae, Klebsiella pneumoniae, Hemolytic streptococcus,
  3. inhibits leptospirosis: andrographolide crude crystal of 1/5000 can inhibit invitro leptospirosis. It is more effective toward the fever type, Australian type, flu type and typhoid type. High concentration can cause leptospirosis to become stiff and to dissolve.
  4. antiviral effect: it can slow down the effect of Enteric cytopathic human orphan virus (ECHO) on cell mutation.
  5. antipyretic effect: deoxyandrographolide, andrographolide, neoandrographolide, 14-deoxy-11,12-didehydroandrographolide possess the antipyretic effect on rabbits with typhoid and with Paratyphoid Fever or fever caused by 2,4- dinitrobenzenephenol.
  6. anti-inflammatory effect:  deoxyandrographolide, andrographolide, neoandrographolide, 14-deoxy-11,12-didehydroandrographolide possess the effect of different degrees of anti-inflammatory effect. Stomach infusion of 1g/kg and inhibits the leakage of capillaries of the abdomen cavaties or skin of mice cause by xylene. (C 6 H 4 ) or acetic acid. It can decrease the exudate of Selve's granuloma cause by fruit of Croton tiglium but it does not affect the growth of the granuloma. It can inhibit the development edema of the paws of the rats caused by ege white; but the effect disappeared after removal of the adrenal glans.
  7. antihypertensive effect: decoction of chuan xin lian can lower the blood pressure of cats under anaesthesia. The stems of chuan xin lian is more effective than the leaves.
  8. effect on pitutary-adrenocortical hormone : large amount of  deoxyandrographolide, andrographolide, neoandrographolide, 14-deoxy-11,12-didehydroandrographolide, can cause the thymuses of young mice into atrophy. This shows that the chemicals of this herb can enhance the function of the adrenocortex. The injectiones made from this herb can stimulate the pitutary - adrenocortex system.

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¤p¹«»P®a¨ßÄéªAªºLD50¬°¡R13.4g/kg ¬ï¤ß½¬Á`¤ºà­¡A¥h®ñ¬ï¤ß½¬¤ºà­ (¬ï¤ß½¬¥Ò¯À) LD50>20g/kg¡A¬ï¤ß½¬¤ºà­ (¬ï¤ß½¬¤A¯À) LD50>40g/Kg¡A¬ï¤ß½¬–£LD50>20g/kg¡Al4-¥h®ñ-11,12-¤G¥h²B¬ï¤ß½¬¤ºà­ (¬ï¤ß½¬ ¤B¯À) LD50>20g/kg¡M¬ï¤ß½¬­W¨ý¯À 10mg/kg ¹ï®a¨ß»P¤p¹«µL¼vÅT¡C®c¤ºª`®g¹ï¤l®c¤º½¤ªº§ÎºA»Pºcµ²¤]µL¼vÅT¡C

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Chemical ingredients:
whole herb: ¥þ¯ó§t:
deoxyandrographolide 0.1% ¥h®ñ¬ï¤ß½¬¤ºà­ 0.1%(¬ï¤ß½¬¥Ò¯À)
andrographolide 1.5% ¬ï¤ß½¬¤ºà­ (¬ï¤ß½¬¤A¯À)
andrographosterin ¬ï¤ß½¬Ír¾J
daucosterol ­JÅÚ½³
andrographoside ¬ï¤ß½¬¤ºà­
neoandrographolide 0.2% ·s¬ï¤ß½¬¤ºà­ (¬ï¤ß½¬ ¤þ¯À) (¬ï¤ß½¬)
homoandrographolide °ª¬ï¤ß½¬¤ºà­
andrographan ¬ï¤ß½¬ÖJ
14-ninandrographolide 14-¥h®ñ¬ï¤ß½¬¤ºà­
19-glucosyl-deoxyandrographolide 19-¸²µå¿}°ò²æ®ñ¬ï¤ß½¬¤ºà­
14-deoxy-l1,12-oxoandrographolide 14-¥h®ñ-1l,12-®ñ¤Æ¬ï¤ß½¬¤ºà­
14-deoxy-11,12-didehydroandrographolide l4-¥h®ñ-11,12-¤G¥h²B¬ï¤ß½¬¤ºà­ (¬ï¤ß½¬ ¤B¯À)
steroid saponin ©T¾J¨m苷
sugar ¿}Ãþ
tannins Âý½è
potassium chloride ´â¤Æ¹[
sodium chloride ´â¤Æ¶u
alkaloids ¥Íª«ÆP
Root: ®Ú§t
mono-O-methylwithin 5-ÖL°ò-7,8,2,3-¥|¥Ò®ñ°ò¶Àà¬
andrographin 5-ÖL°ò-7,8,2-¤T¥Ò°ò¶Àà¬
panicolin 5,2-¤Gßm°ò7,8-¤G¥Ò®ñ°ò¶Àà¬
apigenin-7,4-dimethylether ªàµæ¯À-7,4-¤G¥ÒîÅ
a1-Sitosterol a1-½\Ír¾J
£]-Sitosterol £]-½\Ír¾J
KH2PO4 KH2PO4
dihydroandrographidin A ¤G²B¶Àସ²µå¿}
andrographidin B, C, C, E, F ¶Àସ²µå¿}
Leaves: ¸­§t
deoxyandrographalide ¥h®ñ¬ï¤ß½¬¤ºà­
andrographolide ¬ï¤ß½¬¤ºà­
neoandrograPholide ·s¬ï¤ß½¬¤ºà­
homoandrographolide °ª¬ï¤ß½¬¤ºà­
paniculide A, B, C ÆV®Ö½¬¤ºà­
andragraphan ¬ï¤ß½¬ÖJ
andrographon ¬ï¤ß½¬à¬
andrographosterin ¬ï¤ß½¬©T¾J
£]-Sitosterol-D -glucoside £]-½\©T¾J-D-¸²µå¿}苷
oroxylin-A ¤d¼h¯È¯ÀA
wogonin º~¶ÀÍÁ¯À
flavon ¶Àà¬
iphatic aldehyde ¹¡©M¯×ªÕîÇ
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young leaves and sprouts: ¥®¹à¦U³¡¤À¾¹ºÞ¤Î­F¶b¡B­FªÞµ¥·U¦X²Õ´:
PaniculidesA,B,C ¬ï¤ß½¬¤ºà­A,B,C
Dosage: 9 to 15 g.

The effective ingredients do not not easily dissolve in water. Boiling in water may not be very effective.

9 ~ 15 §J¡C

¥»«~¦³®Ä¦¨¤À¤£©ö·»©ó¤ô¡A¤ô·Î¥i¯à¤£¤Q¤À¦³®Ä¡C

Samples of formulae: See:Acute infection, diarrhea
Modern Research: to be uploaded
Cautions: large  dosage or long term usage may injure stomach function (qi).

Do not uses in cases of :

  1. pregnancy because it can cause miscarriage.
  2. ulcers in duodenum or in stomach.

­G¡B¤Q¤G«ü¸z¼ìºÅ¯f±w¤£©yªA¥Î¡CÃh¥¥´Á¶¡¤£¥i¥Î¡C

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Last update: Oct 21, 2005, 1:37 p.m. RC andrographitis_paniculata.htm  chuan_xin_lian.htm

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