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Arginine      C6H14N4O2       精胺酸


The chemical name of arginine is 2-amino-5-guanidovaleric acid.  It is an essential amino acid,  C6H14N4O2, a major component of proteins, produced by the hydrolysis or digestion of proteins. It is one of the hexone bases (Schulze and Steiger, 1886), and it supplies the amidine group for the synthesis of creatine.  It contains the guanido group that has a pKa of greater than 12, so that it carries a permanent positive charge at physiological pH. It becomes an essential amino acid when the body is under stress or is in an injured state. 

精氨酸化學名為:2-氨基-5-胍基戊酸; L-蛋白氨基酸。它是一種重要的氨基酸,C6H14N4O2,為蛋白質組成重要部份,是水解或消化蛋白质所得的。它是異己酮鹼之一種。

Lack of dietary arginine results in depressed growth. Arginine deficiency syndrome is observed in human babies born with a phosphate synthetase deficiency. Normal growth and development in these infants are achieved by adding arginine to their diet.
Arginine deficiency leads to carbamyl phosphate overproduction in the mitochondria due to inadequate ornithine supply.  Arginine-deficient diets in males causes decreased sperm counts. Free and bound arginine are found in abundance in human  male sperm and arginine has been found to stimulate sperm motility. 

There are two sources of arginine:  arginine in the food chain and free-form arginine from supplements. Food-source arginine is  found in abundance in turkey, chicken and other meats. Nonfood-source arginine is called L-arginine and is created through a fermentation process which separates arginine from all other proteins. In the presence of food and other amino acids, L-arginine  will act like food-source arginine but when L-arginine is separated from its nutrient boundaries by the removal of all other amino acids, then L-arginine undertakes a different role, becoming capable of crossing the blood-brain barrier and stimulating growth
hormone release secreted by the anterior pituitary. 

Growth hormone serum levels peak during adolescence and begin to drop after age 23. Aging reduces natural growth hormone production, which results in added body fat, reduced muscle tissue, slowed healing, lack of elasticity in the skin and reduced  immune function. Human pituitary growth hormone secretion is evidenced in human males, females and children following intravenous administration of 30 grams of arginine (in 30 minutes) in adults and 0.5 grams/kilogram of bodyweight in children.  Female response is somewhat higher than male response. Oral administration of L-arginine also results in the release of Human  Growth Hormone. 

Tumor suppression is evidenced in the presence of L-arginine. In the Barbul study, tumors recurred in 100% of the control  animals. But in the arginine-supplemented group, only about 60% of the tumors recurred and the animals with tumors survived longer. Supplementation of arginine in the diet inhibits development and increase in size of cancerous tumors, both chemically induced and naturally occurring. 

Insulin can block growth hormone release, so high serum insulin levels are counterproductive to growth hormone release. Insulin itself is  capable of stimulating muscle growth, but it also strongly stimulates fat storage. Muscle growth stimulation from insulin is minuscule compared to muscle growth stimulated by growth hormone.
Arginine is a natural constituent of dietary proteins and has a low toxicity in otherwise healthy individuals.



1. OMD

2. Dorland's Illustrated Medical Dictionary

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