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 andrographis_paniculata.htm  chuan_xin_lian.htm

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chuan xin lian ¬ï¤ß ½¬

by: Joe Hing Kwok Chu

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Pharmaceutical name:

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Herba andrographis paniculatae

Biological name:

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Andrographis paniculata (Burm. F.) Nees

Pron. in Japanese:

¤é»yµo­µ¡G

senhinren

Pron. in Korean:

Áú»yµo­µ¡G

chonsimyon

Pron. in Cantonese:

¸f»yµo­µ¡G

cyun1 sam1 lin4

Common Name:

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green chiretta
Distribution:

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Guangdong, Guangxi, Fujian, Yunnan, Sichuan, Jiangsu, Jiangxi provinces

¼sªF¡A¼s¦è¡AºÖ«Ø¡A¤ª«n¡A¥|¤t¡A¦¿Ä¬¡A¦¿¦è µ¥¬Ù¡C

Properties (characteristics)

©Ê¨ý:

bitter, cold

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Channels (meridians) entered:

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lungs, large intestine, bladder

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Actions & Indications:

¥Dªv¡G

clear heat and toxins, cool blood, reduce swelling, for fever in influenza, swelling and pain in throat, boils in mouth and tongue, chronic cough, diarrhea, painful urination, snake bites

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Medical Function: [1]

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Medical Functions:

  1. The whole herb possess antibiotic, antiviral, antipyretic and ridding of parasite effect

  2. decoction of 5 to 40%, to different degrees, inhibits Staphylococcus aureaus, Pseudomonas aeruginosa, Shigella dysenteriae, Klebsiella pneumoniae, Hemolytic streptococcus,

  3. inhibits leptospirosis: andrographolide crude crystal of 1/5000 can inhibit invitro leptospirosis. It is more effective toward the fever type, Australian type, flu type and typhoid type. High concentration can cause leptospirosis to become stiff and to dissolve.

  4. antiviral effect: it can slow down the effect of Enteric cytopathic human orphan virus (ECHO) on cell mutation.

  5. antipyretic effect: deoxyandrographolide, andrographolide, neoandrographolide, 14-deoxy-11,12-didehydroandrographolide possess the antipyretic effect on rabbits with typhoid and with Paratyphoid Fever or fever caused by 2,4- dinitrobenzenephenol.

  6. anti-inflammatory effect:  deoxyandrographolide, andrographolide, neoandrographolide, 14-deoxy-11,12-didehydroandrographolide possess the effect of different degrees of anti-inflammatory effect. Stomach infusion of 1g/kg and inhibits the leakage of capillaries of the abdomen cavaties or skin of mice cause by xylene. (C 6 H 4 ) or acetic acid. It can decrease the exudate of Selve's granuloma cause by ba dou but it does not affect the growth of the granuloma. It can inhibit the development edema of the paws of the rats caused by ege white; but the effect disappeared after removal of the adrenal glans.

  7. antihypertensive effect: decoction of chuan xin lian can lower the blood pressure of cats under anaesthesia. The stems of chuan xin lian is more effective than the leaves.

  8. effect on pitutary-adrenocortical hormone : large amount of  deoxyandrographolide, andrographolide, neoandrographolide, 14-deoxy-11,12-didehydroandrographolide, can cause atrophy of the thymuses of young mice . This shows that the chemicals of this herb can enhance the function of the adrenocortex. The injectiones made from this herb can stimulate the pituitary - adrenal cortex axis.

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 6. §Üª¢¯g§@¥Î¡G ¥h®ñ¬ï¤ß½¬¤ºà­¡A¬ï¤ß½¬¤ºà­¡B¬ï¤ß½¬ 苷¡B²æ¤ô¬ï¤ß½¬¤ºà­§¡¨ã¦³¤£¦Pµ{«×ªº§Üª¢§@¥Î¡Alg/kgÄéªA®É¯à§í¨î¤G¥Ò­f©Î¾L»Ä©Ò­P¤p¹«¥Ö½§©Î¸¡µÄ¤ò²Ó¦åºÞ³q³z©Êªº¼W°ª¡A´î¤ÖSelye¤ó¦×ªÞÅn¤¤¤Ú¨§ªo©Ò­P«æ©Êº¯¥X²G¶q¡A¦ý¹ï¦×ªÞ²Õ´¼W¥ÍµL©úÅã¼vÅT¡A¯à§í¨î³J²M©Ò­P¤j¹«¸}¤ö¤ô¸~ªºµo®i¡A¦ý¤Á°£µÇ¤W¸¢«á§@¥Î®ø¥¢¡C

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 8. ¹ï««Åé - µÇ¤W¸¢¥Ö½è¥\¯àªº¼vÅT¡R ¬ï¤ß½¬¥Ò¡M¤A¡M¤þ¡M¤B¯À©ó¸û¤j¾¯¶q®É¥i¯à¨Ï¨ì¥®¦~¤p¹«¯Ý¸¢µäÁY¡M´£¥Ü¥¦­Ì¥i¯à¼W±jµÇ¤W¸¢¥Ö½è¥\¯à¡C¨äª`®g²G¯à©úÅ㿳¾Ä¤j¹«««Åé - µÇ¤W¸¢¥Ö½è¨t²Î¡C

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(1) «æ©Ê¬r©Ê¡R

¤p¹«»P®a¨ßÄéªAªºLD50¬°¡R13.4g/kg ¬ï¤ß½¬Á`¤ºà­¡A¥h®ñ¬ï¤ß½¬¤ºà­ (¬ï¤ß½¬¥Ò¯À) LD50>20g/kg¡A¬ï¤ß½¬¤ºà­ (¬ï¤ß½¬¤A¯À) LD50>40g/Kg¡A¬ï¤ß½¬–£LD50>20g/kg¡Al4-¥h®ñ-11,12-¤G¥h²B¬ï¤ß½¬¤ºà­ (¬ï¤ß½¬ ¤B¯À) LD50>20g/kg¡M¬ï¤ß½¬­W¨ý¯À 10mg/kg ¹ï®a¨ß»P¤p¹«µL¼vÅT¡C®c¤ºª`®g¹ï¤l®c¤º½¤ªº§ÎºA»Pºcµ²¤]µL¼vÅT¡C

(2) ªø´Á¬r©Ê¡Rµ¹¤j¥Õ¹«»P®a¨ßÄéªA¬ï¤ß½¬¤A¯À1g/kg¡M¨C¤é¤@¦¸¡M³sÄò7¤Ñ¡C¹ï¨äÅé­«¡M¦å¶H¡M¨x¡MµÇ ¥\¯à¤Î¥D­n¾¹©xªº²Õ´¤Á¤ù¥¼¨£¦³©úÅ㪺¼vÅT¡C¬ï¤ß½¬¥Ò¯À¦³¬Û¦Pµ²ªG¡C

Chemical ingredients:

¤Æ¾Ç¦¨¥÷¡G

whole herb:

¥þ¯ó§t:

deoxyandrographolide 0.1%

¥h®ñ¬ï¤ß½¬¤ºà­ 0.1%(¬ï¤ß½¬¥Ò¯À)

andrographolide 1.5%

¬ï¤ß½¬¤ºà­ (¬ï¤ß½¬¤A¯À)

andrographosterin

¬ï¤ß½¬Ír¾J

daucosterol

­JÅÚ½³

andrographoside

¬ï¤ß½¬¤ºà­

neoandrographolide 0.2%

·s¬ï¤ß½¬¤ºà­ (¬ï¤ß½¬ ¤þ¯À) (¬ï¤ß½¬)

homoandrographolide

°ª¬ï¤ß½¬¤ºà­

andrographan

¬ï¤ß½¬ÖJ

14-ninandrographolide

14-¥h®ñ¬ï¤ß½¬¤ºà­

19-glucosyl-deoxyandrographolide

19-¸²µå¿}°ò²æ®ñ¬ï¤ß½¬¤ºà­

14-deoxy-l1,12-oxoandrographolide

14-¥h®ñ-1l,12-®ñ¤Æ¬ï¤ß½¬¤ºà­

14-deoxy-11,12-didehydroandrographolide

l4-¥h®ñ-11,12-¤G¥h²B¬ï¤ß½¬¤ºà­ (¬ï¤ß½¬ ¤B¯À)

steroid saponin

©T¾J¨m苷

sugar

¿}Ãþ

tannins

Âý½è

potassium chloride

´â¤Æ¹[

sodium chloride

´â¤Æ¶u

alkaloids

¥Íª«ÆP

Root:

®Ú§t

mono-O-methylwithin

5-ÖL°ò-7,8,2,3-¥|¥Ò®ñ°ò¶Àà¬

andrographin

5-ÖL°ò-7,8,2-¤T¥Ò°ò¶Àà¬

panicolin

5,2-¤Gßm°ò7,8-¤G¥Ò®ñ°ò¶Àà¬

apigenin-7,4-dimethylether

ªàµæ¯À-7,4-¤G¥ÒîÅ

a1-Sitosterol

a1-¨¦ Ír¾J

£]-Sitosterol

£]-¨¦ Ír¾J

KH2PO4

KH2PO4

dihydroandrographidin A

¤G²B¶Àସ²µå¿}

andrographidin B, C, C, E, F

¶Àସ²µå¿}

Leaves:

¸­§t

deoxyandrographalide

¥h®ñ¬ï¤ß½¬¤ºà­

andrographolide

¬ï¤ß½¬¤ºà­

neoandrograPholide

·s¬ï¤ß½¬¤ºà­

homoandrographolide

°ª¬ï¤ß½¬¤ºà­

paniculide A, B, C

ÆV®Ö½¬¤ºà­

andragraphan

¬ï¤ß½¬ÖJ

andrographon

¬ï¤ß½¬à¬

andrographosterin

¬ï¤ß½¬©T¾J

£]-Sitosterol-D -glucoside

£]-¨¦ ©T¾J-D-¸²µå¿} 苷

oroxylin-A

¤d¼h¯È¯ÀA

wogonin

º~¶ÀÍÁ¯À

flavon

¶Àà¬

iphatic aldehyde

¹¡©M¯×ªÕîÇ

unsaturated ketone

¤£¹¡©Mà¬

young leaves and sprouts:

¥®¹à¦U³¡¤À¾¹ºÞ¤Î­F¶b¡B­FªÞµ¥·U¦X²Õ´:

PaniculidesA,B,C

¬ï¤ß½¬¤ºà­A,B,C

Dosage:

¥Î¶q¡G

9 to 15 g.

The effective ingredients do not  easily dissolve in water. Boiling in water may not be very effective.

9 ~ 15 §J¡C

¥»«~¦³®Ä¦¨¤À¤£©ö·»©ó¤ô¡A¤ô·Î¥i¯à¤£¤Q¤À¦³®Ä¡C

Samples of formulae:

³B¤èÁ|¨Ò¡G

See:Acute infection, diarrhea

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Modern Research:

现¥N¬ã¨s¡G

to be uploaded
Cautions:

¸T§Ò¡G

large  dosage or long term usage may injure stomach function (qi).

Do not use in cases of :

  1. pregnancy because it can cause miscarriage.
  2. ulcers in duodenum or in stomach.

­G¡A¤Q¤G«ü¸z¼ìºÅ¯f±w¤£©yªA¥Î¡CÃh¥¥´Á¶¡¤£¥i¥Î¡C

[1] Zhong Hua Ben Cao    中華本草

¬Ý¬ï¤ß½¬ÄÝ´Óª«¨ë¤ò¬ï¤ß½¬¤§¦¨¤À¬ã¨s

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