Pharmaceutical name:

英文藥名﹕

Botanical name:

學名﹕

Gelsemium elegans  Benth.

Pron. in Japanese:

日語發音﹕

Pron. in Korean:

韓語發音﹕

粵音﹕

ngau1 man5

Other Names:

別名﹕

duan chang cao 斷腸草, ye ge 野葛, da cha teng 大茶藤

Common Name:

英文名﹕

poison hemlock

Distribution:

產地﹕

Properties

(characteristics)﹕

性味﹕

辛﹐溫﹐大毒。

acrid, warm, very toxic

歸經﹕

Medical functions:

藥理﹕

Actions & Indications:

主治﹕

Mainly for external use.

For getting rid of parasites, rheumatoid arthritis. Smash and apply to affected area. Remove after half an hour or may irritate the skin and form blisters.

主要外用。 驅蟲﹐治風濕關節炎。搗爛敷於患處。半小時後 除去﹐不然可能生刺激皮膚而水泡。

Chemical ingredients:

化學成份﹕

Dosage:

用量﹕

daily dosage: 0.1 g to 0.15 g

每日量﹕0.1 克~ 0.15 克。

Samples of formulae

:處方舉例﹕

Modern Research:

現代研究﹕

• Rujjanawate C, Kanjanapothi D, Panthong A.

Laboratory of Natural Products, Faculty of Medicine, Chulabhorn Research Institute, Research Center at Chiangmai University, Chiangmai University, Chiangmai 50200, Thailand. crujjana@med.cmu.ac.th

Gelsemium elegans Benth. (Loganiaceae), a toxic plant indigenous to southeastern Asia, is well known among hill tribes as an effective means for committing suicide.

A crude alkaloidal fraction from its leaves was isolated by conventional acid-base extraction. Tests in animals showed that the alkaloids exerted analgesic and anti-inflammatory effects. At a lethal dose, the alkaloids produced violent clonic convulsions that led to respiratory failure. Since the convulsions could be prevented by pentobarbital or diazepam and potentiated by reserpine, it is postulated that the alkaloids act centrally against GABA action.

PMID: 14522437 [PubMed - indexed for MEDLI

A crude alkaloidal fraction from its leaves was isolated by conventional acid-base extraction. Tests in animals showed that the alkaloids exerted analgesic and anti-inflammatory effects. At a lethal dose, the alkaloids produced violent clonic convulsions that led to respiratory failure. Since the convulsions could be prevented by pentobarbital or diazepam and potentiated by reserpine, it is postulated that the alkaloids act centrally against GABA action.

鉤吻是一種有毒之植物。原生長於東南亞。在山地居民中，它是一種知名用來自殺的東西。

用常規的酸鹼萃取法在樹葉中提出了一種粗生物鹼。用動物實驗表明這生物鹼有止痛和抗炎作用。在致命的劑量下它能致陣攣性抽搐而能導致呼吸衰竭。此抽搐可用戊基巴比妥或地西泮(甘草酸二銨 )加上利血平以防止。有認為此生物鹼能對抗腦內 γ-氨基丁酸。（朱興國譯）原著者：看英文原文第一段。

编者註：γ-氨基丁酸低下可導致陣攣性抽搐。

Toxicity & Cautions:

毒素與禁忌﹕

Whole plant is toxic. It is usually for external use only. The young leaves are especially toxic.

There is no effective antidote. The commonly used therapy is gastric lavage, promoting vomiting and diarrhea. See "Modern Research" item above.

全株有毒。一般只作外用。新生幼葉尤毒。沒有特效 藥。一般處理方法﹕洗胃﹐催嘔﹐催瀉。看上條 “現代研究”。