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Latest update:  Nov 19, 2012; 12:10 a.m. LAH; Last update: Dec 12, 2012;12:22 a.m. LAH

 

she tui 蛇蛻   (in English and Chinese 中英文)

Translated into English by: Joe Hing kwok Chu    朱興國編 譯    

Pharmaceutical name:

英文藥名﹕

Periostracum serpentis

Zoological name of source materials:

拉丁動物學名﹕

Elaphe taeniura Copa (黑眉錦蛇)

Elaphe carinata GŁnther (錦蛇)

Zaocys dhumnades Cantor (烏梢蛇)

Natrix piscator Schneider (漁游蛇)

Pron. in Japanese:

日語發音﹕

shatai; dai sei

Pron. in Korean:

韓語發音﹕

sase

Pron. in Cantonese::

粵音﹕

se4 teoi3

Other Names:

別名﹕

long zi yi 龍子衣,she fu 蛇符,long zi dan yi 龍子單衣,gong pi 弓皮,long pi 龍皮,long dan yi 龍 單衣,she jun 蛇筋,she fu 蛇附,she pi 蛇皮,long zi pi 龍子皮,she tui pi 蛇蛻皮,she ke 蛇 殼,she tui 蛇退,long yi 龍衣,qing long yi 青龍衣,chang chong pi 長虫皮,bai ling yi 白龍衣

Common Name:

英文名﹕

snake slough

Distribution:

產地﹕

Mainly produced in Zhejiang, Guangxi, Sichuan, Jiangsu, Fujian, Anhui, Shaanxi, Yunnan provinces.

主產浙江,廣西,四川,江蘇,福建,安徽 ,陝西,雲南等地。

Properties

(characteristics)﹕

性味﹕

sweet, salty, neutral.

甘,鹹,平。

Channels (meridians) entered:

 

歸經﹕

liver, spleen.

肝,脾。

Medical functions:

藥理﹕

 

Medical functions:

1. The anti-inflammatory effect: Indomethacin (indomethacin, IDM), Phenylbutazone, PB were used as control drugs. Male rats (200-300g body weight) and Dd strain male mice (20g) were used. The feed and water were fed ad libitum. Experimental results show that: 1.1. Acute toxicity test, no significant toxicity. Method preparation: using snake slough boiled water extract, freeze-dried to produce yellow-brown powder. The yield was 5.4%.
1.2: The inhibition of leukocyte mobility effect: Using extract of 20mg/kg intravenously, the  inhibition rate was approximately 51.1% (P <0.01). The inhibition of leukocyte mobility of using daily oral administration of 200mg/kg for 5 days: the inhibition rate was 33.7% (P <0.02 ).

.2. Paw edema inhibition effect: inhibition of edema caused by carrageenan, using oral administering of the herb extract was ineffective. But, using 50mg/kg subcutaneous injection and 20mg/kg intravenous injection showed that using IDM was equally effective in anti-edema effect. After intravenous 20mg/kg2 hours to inflammatory agents, it resulted in an anti-edema effect. In mustard paste (Mustarol) induced edema, the IDM inhibited edema after 7 days of application. Using this herb (snake slough) extract took six days, but  it is the same as using phenylbutazone; there was no persistent anti-edema effect.
3. For vascular hyperpermeability inhibition: dose of 100mg/kg taken orally can inhibit the dextran-induced skin edema. The herb  inhibition rate was 60% (P <0.02). For the  control group using drug IDM10mg/kg, the inhibition rate was 37.5% (P <0.01). The inhibition rate of the spread of pigment extract only was  15% (P <0.05),  Using IDM, the inhibition rate was 72.6% (P <0.01), This indicates a different mechanism of action of the two drugs.(she tui and IDM).
4. The thermal hemolysis of red blood cells inhibitory effect of the extract of 4mg and 12mg was 20.5% (P <0.01) and 48% (P <0.01). That was equivalent to IDM1mg, phenylbutazone or 5mg hemolysis inhibition.

藥理﹕ 

1.抗炎症作用:採用煮沸的蛇蛻水提取物,凍干後得黃褐色粉末,得率為5.4%。用消炎痛(Indomethacin,IDM)、保秦松(Phenylbutazone,PB)作為對照藥物。動物採用雄性大鼠(200-300g體重)和 Dd系雄性小鼠(20g)。飼料、水自由攝取。實驗結果表明:

1.1.急性毒性試驗無明顯的毒性。

1.2.對白血球游走的抑制作用表明:提取液20mg/kg靜脈注射,抑制率約 51.1%(P<0.01),每天口服200mg/kg,5天抑制率為33.7%(P<0.02)。
  2.對足跖浮腫的抑制作用:對角叉菜膠所致浮腫的抑制作用,口服無效。50mg/kg皮下注射和20mg/kg靜脈注射呈現與 IDM同等顯著的抗浮腫作用。給發炎劑後,靜脈注射20mg/kg2小時後出現明顯的抗浮腫作用。對芥末糊(Mustarol)所致浮腫的抑制作用,IDM在7天後有抑制浮腫的作用。蛇蛻提取液從第6天開始有效,但與保泰鬆一樣都無持續抗浮腫作用。
  3.對血管通透性亢進的抑制作用:劑量為100mg/kg口服對葡聚糖所致皮膚浮腫抑制率 60%(P<0.02)。口服對照藥物 IDM10mg/kg抑制率為37.5%(P<0.01),但對色素擴散的抑制率,提取液僅為15%(P<0.05),IDM則為72.6%(P<0.01),這表明兩種藥物的作用機理不同。
  4.對紅血球熱溶血的抑制作用:提取液4mg和12mg的抑制作用分別為20.5%(P<0.01)和48%(P<0.01);相當於IDM1mg,保泰鬆 5mg 對溶血的抑制作用。
 

Actions & Indications:

主治﹕

Being used in infantile convulsion, spasm, incipient cataract, throat inflammation, boils, itchy skin,

用於小兒驚風,抽搐痙攣,翳障,喉痺,疔腫 ,湯傷,皮膚瘙痒。

Chemical ingredients:

化學成份﹕

The slough of Natrix piscator contains:漁游蛇的蛇蛻含:
collagen骨膠原
amino acids氨基酸
glycogen糖原
nucleic acid核酸
aminopeptidase氨肽酶
β-glucuronidaseβ-葡萄糖醛酸酶
lactate dehydrogenase乳酸脫氫酶
isocitrate dehydrogenase異檸檬酸脫氫酶
di- & triphosphopyridine nucleotide diaphorase二及三磷酸吡啶核苷酸黃遞酶
esterase酯酶
glucose -6-- phosphate dehydrogenase葡萄糖-6-磷酸脫氫酶
phosphorylase磷酸化 酶

Daily Dosage:

每日用量﹕

2 to 3 g in decoction. or make into powder and swallow: 0.3 to 0.6 g

2~3 g;研末吞服 0.3~0.6 g

Samples of formulae:

處方舉例﹕

For treatment of urination difficulty:

Name of formula: yu long san (jade dragan powder)

Composition:  yu zan hua 6 g, she tui 6 g, ding xiang 3 g.

Make into powder. Use 3 g each time. Stir with rice wine. Take orally.

 


治小便不通:

藥方名:玉龍散《醫學指南》

組成:玉簪花蛇 蛻各二錢,丁香一錢。

共為末,每服一錢,酒調送下。

Modern Research:

現代研究﹕

 

Toxicity & Cautions:

毒素與禁忌﹕

Not to use during pregnancy.

孕婦忌用。

 

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