FEV1 — Complementary and Alternative Healing University

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The Forced Expiratory Volume in 1 second (FEV1) is the volume of air expired in the first second. This is an important predictor of outcomes in patients with COPD.

predicted FEV1 in liters for males (Boren, 1966) =

= (0.094 * (height in inches)) - (0.028 * (age in years)) - 1.59 =

FEV1 in liters for White males 15-79 years (Cherniack, 1972) =

= (0.09107 * (height in inches)) - (0.0232 * (age in years)) - 1.50723

FEV1 in liters for White females 15-79 years (Cherniack, 1972) =

= (0.06029 * (height in inches)) - (0.01936 * (age in years)) - 0.18693

FEV1 in liters for Hispanic males 25-80 years (Coultas, 1988) =

= (3.7708 * (height in meters)) - (0.0288 * (age in years)) - 1.6205

FEV1 in liters for Hispanic females 25-80 years (Coultas, 1988) =

= (3.2138 * (height in meters)) - (0.0243 * (age in years)) - 1.4184

FEV1 in liters for White males 15-91 years (Crapo, 1981) =

= (0.0414 * (height in cm)) - (0.0244 * (age in years)) - 2.190

FEV1 in liters White females 15-84 years (Crapo, 1981) =

= (0.0342 * (height in cm)) - (0.0255 * (age in years)) - 1.578

FEV1 in liters for Hispanic males 25-75 years (Crapo, 1990) =

= (0.0451 * (height in cm)) - (0.0301 * (age in years)) - 2.7721

FEV1 in liters Hispanic females 20-80 years (Crapo, 1990) =

= (0.0378 * (height in cm)) - (0.0189 * (age in years)) - (0.0048 * (weight in kilograms)) - 2.1371

FEV1 in liters for Chinese males 20-66 years (Da Costa, 1971) =

= (0.0267 * (height in cm)) - (0.0189 * (age in years)) - 0.774

FEV1 in liters for Chinese females 20-66 years (Da Costa, 1971) =

= (0.017 * (height in cm)) - (0.0175 * (age in years))+ 0.232

FEV1 in liters for White males 65-85 years (Enright, 1993) =

= (0.0378 * (height in cm)) - (0.0271 * (age in years)) - 1.73

FEV1 in liters for White females 65-85 years (Enright, 1993) =

= (0.0281 * (height in cm)) - (0.0325 * (age in years)) - 0.09

FEV1 in liters in adult males 20 - 65 years of age (Grimby, 1963) =

= (3.44 * (height in meters)) - (0.033* (age in years)) - 1.00

FEV1 in liters in adult females 18 - 72 years of age (Grimby, 1963) =

= (2.67 * (height in meters)) - (0.028* (age in years)) - 0.54

FEV1 in liters for White males 25-85 years (Knudson, 1983) =

= (0.0665 * (height in cm)) - (0.0292 * (age in years)) - 6.5147

FEV1 in liters for White females 20-88 years (Knudson, 1983) =

= (0.0309 * (height in cm)) - (0.0201 * (age in years)) - 1.405

FEV1 in liters for males 18-66 years (Kory, 1961) =

= (0.037 * (height in cm)) - (0.028 * (age in years)) - 1.59

FEV1 in liters for White males 20-84 years (Morris, 1971) =

= (0.092 * (height in inches)) - (0.032 * (age in years)) - 1.26

FEV1 in liters for White females 20-84 years (Morris, 1971) =

= (0.089 * (height in inches)) - (0.025 * (age in years)) - 1.932

FEV1 in liters for Black males 15-74 years years (Mustafa, 1977) =

= (0.046 * (height in cm) - (0.022 * (age in years)) - 3.864

FEV1 in liters for White males 18-86 years years (Roberts, 1991) =

= (3.961 * (height in meters)) - (0.033* (age in years)) - 1.558

FEV1 in liters for White females 18-86 years (Roberts, 1991) =

= (3.321 * (height in meters)) - (0.025* (age in years)) - 1.394

FEV1 in liters for Black males 20-92 years years (Stinson, 1981) =

= (0.096 * (height in inches)) - (0.021 * (age in years)) - 2.51

FEV1 in liters for Black females 20-92 years (Stinson, 1981) =

= (0.062 * (height in inches)) - (0.017 * (age in years)) - 0.951

Interpretation:

• The FEV1 reflects the severity of pulmonary impairment in obstruction.

FEV1	Interpretation
> 80% predicted	normal
66-80% predicted	mild obstruction
50-65% predicted	moderate obstruction
< 50% predicted	severe obstruction

References:

Anthonisen NR, et al. Prognosis in Chronic Obstructive Pulmonary Disease. Am Rev Respir Dis. 1986; 133:14-20.

Berglund E, Birath G, et al. Spirometric studies in normal subjects. Forced expirograms in subjects between 7 and 70 years of age. Acta medicia Scandinavica. 1963; 173: 185-192

Boren HG, Kory RC, et al. The Veterans Administration-Army cooperative study of pulmonary function - II. The lung volume and its subdivisions in normal men. Am J Med. 1966; 41:96-114 (page 104).

Cherniack RM, Raber MB. Normal standards for ventilatory function using an automated wedge spirometer. Am Review Respir Dis. 1972; 106: 38-46.

Coultas DB, Howard CA, et al. Spirometric prediction equations for Hispanic children and adults in New Mexico. Am Rev Respir Dis. 1988; 138: 1386-1392. (Table 4, page 1390).

Crapo RO, Morris AH, Gardner RM. Reference spirometric values using techniques and equipment that meet ATS recommendations. Am Rev Respir Dis 1981; 123:659-664.

Crapo RO, Jensen RL, et al. Normal spirometric values in healthy Hispanic Americans. Chest. 1990; 98: 1435-1439.

Da Costa JL.Pulmonary function studies in healthy Chinese adults in Singapore. Am Rev Respiratory Disease. 1971; 104: 128-131.

Enright PL, Krnmal RA, et al. Spirometry reference ranges for women and men 65 to 85 years of age. Cardiovascular Health Study. Am Rev Respir Dis. 1993; 147: 125-133.

Ewald G, McKenzie C (editors). Manual of Medical Therapeutics, 28th edition. Little, Brown and Company. 1995. page 242

Grimby G, Soderholm B. Spirometric studies in normal subjects. III. Static lung volumes and maximum voluntary ventilation in adults with a note on physical fitness. Acta Medica Scandinavica. 1963; 173: 199-206.

Knudson RJ, Lebowitz MD, et al. Changes in the normal expiratory flow-volume curve with growth and aging. Am Rev Respir Dis. 1983; 127: 725-734.

Kory RC, Callahan R, et al. The Veterans Administration-Army Cooperative study of pulmonary function. I. Clinical spirometry in normal men. Am J Medicine. 1961 (February); 30: 243-258

Morris JF, Koski A, Johnson LC. Spirometric standards for healthy nonsmoking adults. Am Rev Respir Dis. 1971; 103: 57-67.

Mustafa KY. Spirometric lung function tests in normal men of African ethnic origin. Am Rev Respir Dis. 1977; 116: 209-213

Roberts CM, MacRae KD, et al. Reference values and prediction equations for normal lung function in a non-smoking white urban population. Thorax. 1991; 46: 643-650.

Ruppel GE. Manual of Pulmonary Function Testing, Sixth Edition. Mosby. 1994. pages 461-462.

Stinson JM, McPherson GL, et al. Spirometric standards for healthy Black adults. J National Medical Association. 1981; 73: 729-733

Wanger J. Pulmonary Function Testing. A Practical Approach. Second Edition. Williams & Wilkins. 1996. Table A4.2, page 274.