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(in English and Chinese 中英文)

 

 

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Translated by: Joe Hing Kwok Chu    

 

In general, the diagnosis of gastroesophageal reflux disease includes the following methods:

 

1. measurement of pH: That is a measure of change in the esophageal pH. Its approach is to put a very sensitive electrodes into the esophagus, where the pH changes recorded by microcomputer are being compared with the symptoms.

 

2. Titration test: perfusing certain concentration and certain volume of acid into the stomach or esophagus, and then measure the changes within the esophagus. If the lower esophageal sphincter function is normal, the pH value should be within the esophagus will revert back to five or six pH or more. If there is acid reflux phenomenon, esophageal pH will be sustained or prolonged decline.

 

e. Examination with X-ray on the esophagus and with endoscopic photography can be used. Basically, esophageal ulcers or complications has been formed, or patients already have narrowing esophagi, high diagnosis rate can be achieved, while patients with early disease, this diagnostics is just mildly useful.

 

The purpose of treatment is to stop the occurring of the reflux. The main treatment are mainly as follows:

 

Conservative treatment: including lifestyle changes, try not to eat before going to bed, do not eat too much, to avoid exercise after eating or sleeping, within one or two hours after eating do not lie down, use higher pillows when going to bed, using gravity principle to reduce food and digestive juices in the stomach to flow back to the esophagus. Try to avoid some of the diet that can cause lower esophageal sphincter to relax, such as high-fat food, wine, coffee, chocolate etc. Smoking will also aggravate symptoms. Obesity also cause stomach to rise and relaxes the lower esophageal sphincter. So quit smoking, lose weight are required. Relaxing the mood and reducing anxiety is important. If there are diseases in taking some medication, minimize the doses. Medication such as theophylline used in asthma can also relax the lower esophageal sphincter and increase the chance of acid reflux.

 

If these methods are ineffective, consider taking drugs. There are basically two major categories:

 

1. One is to reduce the acid, the use of antacids to neutralize the acidity of the stomach and esophagus, these include general stomach tablets (Aluminum Hydroxide you use or Magnesium Hydroxide) with a direct role in the parietal cells, reducing gastric acid produced knot histamine antagonist, and proton pump inhibitors (that is Omeprazole, Cimetidine, Famotidine and the like). As for sterilization therapy (eradication therapy for Helibacter pylori), although it was in use, but in the in treatment of acid reflux in esophageal diseases,  it does not have an important role.

 

2. Another class of drugs is the stomach and intestines accelerator, which can strengthen the lower esophageal sphincter contractility, accelerate gastric emptying to prevent reflux. Typically the drugs will have some effect, but some patients may require treatment for some time.

 

But if you just like to take medication, while ignoring the adjustment of lifestyle and food choices and then withdrawal symptoms often come back soon. To be thorough and effective  all parties should be aware that it is important to have regular exercises.


If users have not been able to use drugs to improve the symptoms or complications and have been generated lower esophageal stenosis, then surgery should be considered. Currently in the bottom of the gastric folds forming technique works best, which is to use the lower part of the stomach and the esophagus fenced so as to form a barrier to further prevent backflow avoid. But this is the last resort. It is better not to use often.

Note: lower esophageal sphincter (LES) (a ring of smooth muscle fibers at the junction of the esophagus and stomach, also called cardiac sphincter, gastroesophageal sphincter)

 

 

資料來源:

http://www.mmh.org.tw/gi/patient_corner/faqs/faq4.htm

 

一般說來,胃食道逆流疾病的診斷方式,包括有以下幾種方法:1. 酸鹼度之測定:即是測量食道內酸鹼度pH值的改變。其作法是把一個極敏感的電極放置入食道中,藉由微電腦記錄其中酸鹼度的變化,並注意這改變與症狀的關係。

 

2. 滴定測驗:就是灌注一定濃度、一定體積的酸液到胃或食道中,再測定食道內的變化。如果下食道括約肌的功能健全而無逆流發生時,食道內的酸鹼值應應會回復到五或六以上。如果有逆流現象,此時食道內的酸鹼值會有持續或長時間的下降。此外X光食道攝影與內視鏡:基本上對已經形成食道潰瘍或併發症,例如已有狹窄者的病患,診斷率較高,而對早期或輕微的病人用處不大。

 

治療的目的就在於阻止逆流的發生。主要治療方式可大別如下。保守治療:包括生活習慣的改變,盡量不要在睡前吃東西,勿暴飲暴食,避免飯後運動或睡覺,進食後一兩小時不要平躺,睡覺時把床頭抬高或墊高枕頭,利用重力原理來減少胃內食物與消化液逆流的可能。飲食上儘量避免一些會引起食道下括約肌放鬆的食物,例如脂肪較高的食物酒、咖啡、巧克力等等。抽煙也會加重症狀。過胖也會使胃上升,食道下括約肌鬆弛。因此戒煙、減重都是必須的。心情上亦必須放輕鬆,減少焦慮。若有其他疾病在服用,一些藥物則盡量減少劑量,例如氣喘使用的 茶鹼(theophylline) ,也會使食道下括約肌鬆弛。

 

若這些方法無效,才考慮到藥物,大致有兩個大方向:]

 

1. 是減少酸液,利用制酸劑來中和胃與食道內的酸度,這類包括一般的胃片(如氫氧化鋁或氫氧化鎂)與直接作用在胃壁細胞,減少胃酸產生的組織胺結抗劑,與質子幫浦抑制劑(就是Omeprazole,Cimetidine,Famotidine 之類)。至於殺菌療法 (eradication therapy for Helibacter pylori) ,雖然有人在使用,但在治療逆流性食道疾病的角色,並不重要。

 

2. 另一類藥物則是胃腸蠕動促進劑,可加強食道下括約肌的收縮力,加快胃排空以阻止逆流。通常藥物都會有一定的效果,只是一些病患可能需要治療好一段時間。

 

不過如果只是想藉著藥物治療,而忽略了生活方式之調整,以及及食物的選擇,則停藥後症狀常常很快會再來。所以若要徹底有效治療,各方面都須注意,持之有恆。


若是症狀一直無法使用藥物改善時,或是有了併發症已經產生食道下端的狹窄,例如就要考慮外科手術了。目前以胃底部皺襞形成術效果最好,這是利用部份的胃將食道下端圍起來,藉以形成一個加強防止逆流的障避。不過這已是最終手段,少用為妙。
 

 

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