Chronic Leukemia

by: Joe Hing Kwok Chu       

Treatment of Chronic Myelogenous Leukemia (CML)  看中文

Name of Formula: qing huang san 青黃散方

Prescription:

Mix two herbs--qing dai and xiong huang--at the ratio of 9:1.

Grind them into fine powder. Load the powder into capsules.

Dosage:

For inducing remission of Chronic Myelogenous Leukemia:

take 6 to 14 g per day, divided into three servings and taken after meals.

For maintenance of remission of Chronic Myelogenous Leukemia:

 take 3 to 6 g per day, divided into two or three servings and taken after meals.

Adjustments of Formula:

Adjust the formula according to the syndrome.

With obvious xue yu (blood clots), add ge xia zhu yu tang.

With qixu and xue xu (blood deficient), add ba zhen tang.

With piyangxu, add xiao jian zhong tang.

Effectiveness:

The clinical experience of using this formula in conjunction with chemotherapy

has been documented by Zhou Ai Xiang at the Xi Yuan Hospital, part of the

Beijing Chinese Medicine Research Institute.

Total patients: 25

Compete remission: 18 (72%)

Partial remission: 7 (28%)

Typically, after 10.1 days, the sizes of the spleens started to shrink. In 11.4 days,

the symptoms had either subsided or disappeared.

Active Ingredients:

The active ingredients of qing dai are ding yu hong (indirubin) and

ding lan (indigo, indigotin). The active ingredient of xiong huang (realgar) is

arsenic sulfite (As₂S₃).

Explanation as to Efficacy:

Traditional theory maintains that leukemia is caused by toxic yu

(obstruction in the blood), obstructing the organ (zang fu), the channels (jing luo),

and the bone marrow. If the toxic yu is not expelled, new blood will not be produced.

The use of these two herbs--qing dai and xiong huang--as directed above and in

conjunction with chemotherapy, can achieve the twin goals of ridding of yu and

promoting new blood.

Side Effects:

Possible side effects of this formula include nausea, stomach and solar plexus

discomfort, diarrhea, and perhaps blood in the stool (caused by bleeding in the

digestive tract).

慢性粒細胞性白血病

青黃散方

功能主治﹕消腫散淤﹐涼血解毒。治慢性粒細胞性白血病。

青黛 9 份﹐雄黃 1 份。研細末。裝膠囊。誘導緩解劑量為每日6 ~14 克。分三次飯後服。維持緩解劑量為每天3 ~ 6 克。分二次飯後服。

療效﹕

病人共25人。完全緩解18例 (72%)。部份緩解7例(28%)。用藥後症狀明顯好轉或消失時間為11.4天。平均10.1天脾臟開始縮小。

處方來源﹕北京中醫研究所﹐西苑醫院﹐周靄祥

以下取材自浙江中醫學院。

http://www.zjtcm.net/wljx/Medicine/kejian5/PART144/02.HTM

1． 马蓝叶制成的青黛含靛玉红（indirubin）、靛蓝（indigo）、靛棕（indo-brown）、靛黄（indo-yellow）、谷肮、鞣酸、蜡质及钾、钠、钙、镁等无机盐、异靛蓝（isoindigo）。

2． 蓼蓝叶制成的青黛含靛玉红、靛蓝、N-苯基-2-萘胺、β-谷甾醇、虫漆蜡醇（lacecerol）。

3． 菘青叶制成的青黛含靛玉红、靛蓝、色胺酮（tryplanthrin）。

4． 野青樹地上部制成的青黛薄层层析显示也含有靛玉红和靛蓝。

*:靛蓝与靛玉红互为同分异构体,但靛蓝无抗癌活性,可见靛玉红的构效关系值得深入研究。

The chemical formulae of indirubin and indigotin are the same but the structures are different, but indigotin does not possess the anti cancer characteristics. The structure of indirubin deserves further study.

Last update: Sept 28, 2003 0:38 a.m.

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