[Clinical study of 96 cases with chronic hepatitis B treated with jiedu yanggan gao by a double-blind method].

[Article in Chinese]
Chen Z.

   本文报道以双盲法治疗慢性乙型肝炎,

观察组51例用中药复方解毒养肝膏,

对照组45例用焦三仙膏。

治疗後

观察组（解毒养肝膏）ALT、AST、TTT 复常率分别为27.3%,66.7%52.0%;

对照组（焦三仙膏）分别为9.1%、22.2%、44.4%。

观察组（解毒养肝膏）：HBsAg,DNAP,HBV-DNA 阴转率分别为20.0%、34.2%、31.6%;

而对照组（焦三仙膏）则分别为6.7%、10.8%、17.6%。

总有效率观察组（解毒养肝膏）为74.5%,

对照组（焦三仙膏）为24.4%,

两组差异有统计学意义。

  ALT AST TTT HBsAg DNAP HBV-DNA
观察组（解毒养肝膏）恢復率 27.3% 66.7% 52.0% 20.0% 34.2% 31.6%
对照组（焦三仙膏）  恢復率 9.1% 22.2% 44.4% 6.7% 10.8% 17.6%

Abstract

This paper reported 96 cases with chronic hepatitis B treated by a double-blind method.

All 96 cases belong to the virus-duplication-type with positive HBsAg for over one year. Among them 65.5% of cases HBeAg, DNAP and HBV-DNA were positive. 20.8% of cases were positive in two out of the above tests. 13 data were compared statistically between two groups, and proved to be comparable (P greater than 0.05) before treatment.

 

There were :

51 cases of observation group(OG) and

45 cases of control group (CG). OG was treated

with Jiedu Yanggan Gao consisting of :

Herba Artemisiae Yinchenhao茵陳蒿, Herba Taraxaci Mongolici cum Radice 蒲公英, Semen Plantaginis  車前子, Herba Cephalenoplos cum radix  小薊, Herba hedyotidis Diffusae 白花蛇舌草, Flos Chrysanthemi Indici 野菊花, Rhizoma Smilacis Glabrae 土伏苓, Radix Astragali 生黃耆, Cortex Moutan Radicis 丹皮, Fructus Polygonii Orientalis水紅花子, Radix Paeoniae Alba 白芍, Rhizoma Polygonati 黃精, etc.).

 

茵陳蒿，蒲公英，車前子，小薊，白花蛇舌草，野菊花，土伏苓，生黃耆，丹皮，丹參，水紅花子，白芍，黃精。

每劑製成糖漿100ml. 每服20ml, 每日三次。

CG was prescribed with three charred medicinal herbs 焦三仙 (charred Fructus Crataegi 焦山楂, charred Fructrus Hordei Germinatus, charred Medicata Fermentita Fujianensis Massa 焦神麴).

The average duration of treatment was five months.

 

 

 27.3% and 66.7% of cases' ALT, AST returned to normal respectively in OG after treatment.

However, in CG they were 9.1% and 22.2% (P less than 0.05). TTT returned to normal in 52% cases of OG and 44% in CG (P greater than 0.05). 20% cases HBeAg shifted to negative in OG, but 6.7% in CG. Cases with negative DNAP in OG occupied 34.2%, but 10.8% in CG. 31.6% cases' HBV-DNA changed to negative in OG, while 17.6% in CG. After comprehensive judgement, the total effective rate was 74.5% in OG and 24.4% in CG respectively (P less than 0.001). Eight cases were basically cured in OG and one case in CG. After one year's follow-up, one recurred in eight patients of OG, however the only one cured in CG still relapsed.