Complementary and Alternative Healing
ALT (serum glutamic pyruvic transaminase, SGPT)
ALT is a liver enzyme that plays a role in protein metabolism, like AST (asparate aminotransferase).
Elevated alanine aminotransferase predicts new-onset type 2 diabetes .
Liver damage from hepatitis B or C, or from drugs: slight elevated serum levels of ALT can be a sign of :
Toxic hepatitis: 30 to 50 times normal values of serum ALT
Mycardial infarction: no or only minor elevations of serum ALT
The AST/ALT ratio is occasionally used in the differential diagnosis of liver disease.
Elevated along with AST:
Drug induced acute liver cell injury
Elevated to a Lesser Degree and Frequency than AST:
Acute alcoholic liver disease
Liver passive congestion
Long standing extra hepatic bile duct obstruction
Metastatic tumor of the liver
Drugs that can cause lower levels: acetic acid (indomethacin), carbenicillin, clindamycin, digitalis, erythromycin, gentamicin, lincomycin, mithramycin, spectinomycin, tetracycline, meperdine, (demerol), morphine, codeine, methyldopa, granethidine, salicylates, rifampin,fluazepam (Dalmane), oral contraceptives, and propranolol (Inderal).
See Chinese herb therapy for hepatitis B.
 Diabetes. 2004 Nov;53(11):2855-60.
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